Machete finds himself devastated when the cartel kills his girlfriend Sartana. But his next mission gives him the opportunity to let off steam: He has to kill the cartel boss Mendez. This gangster is close to drive a rocket attack on the United States. We all know Machete is good at killing but it is not so easy this time. Mendez had the detonator connected to his own heartbeat. Machete looks for help from the ingenious weapon expert Luther Voz. But Luther is busy with his own plan: founding a new society in space. Which logically leads to mankind on earth being extinguished. Suddenly, Machete faces two dangers at once.